Article

<i>p53</i> deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects

2018-02-27

Abstract excerpt

<h4>ABSTRACT</h4> Building a cerebral cortex of the proper size involves balancing rates and timing of neural stem cell (NSC) proliferation, neurogenesis, and cell death. The cellular mechanisms connecting genetic mutations to brain malformation phenotypes are still poorly understood. Microcephaly may result when NSC divisions are too slow, produce neurons too early, or undergo apoptosis, but the relative contrib...

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Literature Corpus work: 3f818167-b5db-5b67-8f33-129aa5bf6a68
DOI: 10.1101/272393

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