Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis

20 Nov 2020

Abstract excerpt

Abstract The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gut microbiota and health
Share to Helicobacter pylori-related gastroenterology studies
Share to Immune Response and Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33219235
DOI: 10.1038/s41467-020-19691-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesisPMID 33219235Read ↗

Validation studies for germ-free Smad3 -/- mice as a bio-assay to test the causative role of fecal microbiomes in IBDSemantic proximity Read ↗

OLFM4 modulates intestinal inflammation by promoting IL-22+ILC3 in the gutSemantic proximity Read ↗

Toll‐like receptor 4 regulates spontaneous intestinal tumorigenesis by up‐regulating IL‐6 and GM‐CSFSemantic proximity Read ↗

Bacterial Infection of Smad3/Rag2 Double-Null Mice with Transforming Growth Factor-β Dysregulation as a Model for Studying Inflammation-Associated Colon CancerSemantic proximity Read ↗

Expression of FIBCD1 by intestinal epithelial cells alleviates inflammation-driven tumorigenesis in a mouse model of colorectal cancerSemantic proximity Read ↗

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.Semantic proximity Read ↗

Loss of C3aR induces immune infiltration and inflammatory microbiota in a new spontaneous model of colon cancerSemantic proximity Read ↗

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiotaSemantic proximity Read ↗

The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Colonic Inflammation and Tumorigenesis in MiceSemantic proximity Read ↗

Dissecting the respective roles of microbiota and host genetics in the susceptibility of <i>Card9</i> <sup>-/-</sup> mice to colitisSemantic proximity Read ↗

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.Semantic proximity Read ↗

Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.