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Article

Phosphorylation of the RB C-terminus regulates condensin II release from chromatin.

The Journal of biological chemistry - 1 Jan 2000

Kim Seung J, MacDonald James I, Dick Frederick A

Abstract excerpt

The retinoblastoma tumor suppressor protein (RB) plays an important role in biological processes such as cell cycle control, DNA damage repair, epigenetic regulation, and genome stability. The canonical model of RB regulation is that cyclin-CDKs phosphorylate and render RB inactive in late G1/S, promoting entry into S phase. Recently, monophosphorylated RB species were described to have distinct...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33219128
DOI: 10.1074/jbc.RA120.016511
PMCID: PMC7948394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of the RB C-terminus regulates condensin II release from chromatin.PMID 33219128Read ↗

Twists in views on RB functions in cellular signaling, metabolism and stem cells.Semantic proximity Read ↗

Post-translational modifications on the retinoblastoma proteinSemantic proximity Read ↗

PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation.Semantic proximity Read ↗

Distinct Mechanisms for Regulating the Tumor Suppressor and Antiapoptotic Functions of RbSemantic proximity Read ↗

Phosphorylation of CAP-G is required for its chromosomal DNA localization during mitosis.Semantic proximity Read ↗

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.Semantic proximity Read ↗

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment.Semantic proximity Read ↗

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.Semantic proximity Read ↗

The amino terminus of the retinoblastoma (Rb) protein associates with a cyclin-dependent kinase-like kinase via Rb amino acids required for growth suppression.Semantic proximity Read ↗

pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.Semantic proximity Read ↗

Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation.Semantic proximity Read ↗

Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.Semantic proximity Read ↗

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