Article
Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2016
Chuang Linda Shyue Huey, Khor Jian Ming, Lai Soak Kuan, Garg Shubham, Krishnan Vaidehi, Koh Cheng-Gee, Lee Sang Hyun, Ito Yoshiaki
Abstract excerpt
The Runt-related transcription factors (RUNX) are master regulators of development and major players in tumorigenesis. Interestingly, unlike most transcription factors, RUNX proteins are detected on the mitotic chromatin and apparatus, suggesting that they are functionally active in mitosis. Here, we identify key sites of RUNX phosphorylation in mitosis. We show that the phosphorylation of threonine 173 (T173)...
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