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Article

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.

Cell - 17 Sept 1999

Harbour J W, Luo R X, Dei Santi A, Postigo A A, Dean D C

Abstract excerpt

We present evidence that phosphorylation of the C-terminal region of Rb by Cdk4/6 initiates successive intramolecular interactions between the C-terminal region and the central pocket. The initial interaction displaces histone deacetylase from the pocket, blocking active transcriptional repression by Rb. This facilitates a second interaction that leads to phosphorylation of the pocket by Cdk2 and disruption of...

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Identifiers

PMID: 10499802
DOI: 10.1016/s0092-8674(00)81519-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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