Article
Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups.
Pharmacogenomics - 1 Jul 2015
He Yijing, Hoskins Janelle M, Clark Scott, Campbell Nathan H, Wagner Kim, Motsinger-Reif Alison A, McLeod Howard L
Abstract excerpt
AIM: To evaluate the potential usefulness of selected SNPs to predict specific HLA alleles that are associated with drug-induced hypersensitivity reactions (HSR) in different ethnic groups. METHODS & RESULTS: Five specific HLA alleles known to predict HSR were tagged by seven SNPs (rs1061235-HLA-A*31:01; rs2395029-HLA-B*57:01; rs3909184-HLA-B*15:02; rs9469003-HLA-B*58:01; rs3117583-HLA-B*58:01;...