Article
Genome-Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Feb 2026
Wang Sijia, Wang Meiyun, Zhang Peng, Cheng Jingliang, Zhang Longjiang, Zhu Wenzhen, Qiu Shijun, Geng Zuojun, Cui Guangbin, Yu Yongqiang, Liao Weihua, Zuo Xi-Nian, Zhang Hui, Gao Bo, Xu Xiaojun, Han Tong, Yao Zhenwei, Zhang Quan, Liu Feng, Xu Qiang, Xu Jiayuan, Fu Jilian, Liu Nana, Ji Yuan, Tang Jie, Guo Lining, Liu Mengge, Xiao Xiaoxiao, Liu Xiaoxuan, Li Wei, Wang Caihong, Wei Wei, Shi Dapeng, Lui Su, Yan Zhihan, Chen Feng, Zhang Jing, Shen Wen, Miao Yanwei, Wang Dawei, Gao Jia-Hong, Yang Yunjun, Xu Kai, Xian Junfang, Zhang Bing, Zhang Xiaochu, Ye Zhaoxiang, Yu Le, Qin Wen, Liang Meng, Yu Chunshui
Abstract excerpt
Brain structure and function show substantial individual differences, finely controlled by genes, environments, and their interactions. Despite the increasing knowledge about genetic and environmental main effects, gene-environment interaction effects on brain phenotypes remain elusive. This study investigates genome-wide by environment (41 exposures) interactions on 598 brain imaging phenotypes in 7084 healthy...
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