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Roles of Genetic Predisposition and Mediation of Biological Age Acceleration in the Association Between Air Pollution and Dementia.

The journals of gerontology. Series A, Biological sciences and medical sciences - 5 May 2025

Jiang Zhou, Yan Yu, Qi Jike, Liu Yuxin, Jiang Yuchen, Zhang Hao, Chen Hao, Guan Xinying, Zhang Pan, Wang Ting, Zeng Ping

Abstract excerpt

BACKGROUND: Air pollution exposure (both individual and joint) is associated with dementia, but its relation to early-onset dementia (EOD) and late-onset dementia (LOD) remains inconclusive. Meanwhile, the modification by genetic predisposition and mediation by accelerated biological aging are also unclear. METHODS: A cohort of 285 774 dementia-free participants from the UK Biobank was analyzed. Exposure levels...

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PMID: 40037565
DOI: 10.1093/gerona/glaf046

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