Article
Cryo-EM structure of influenza virus RNA polymerase complex at 4.3 Å resolution.
Molecular cell - 5 Mar 2015
Chang Shenghai, Sun Dapeng, Liang Huanhuan, Wang Jia, Li Jun, Guo Lu, Wang Xiangli, Guan Chengcheng, Boruah Bhargavi M, Yuan Lingmin, Feng Feng, Yang Mingrui, Wang Lulan, Wang Yao, Wojdyla Justyna, Li Lanjuan, Wang Jiawei, Wang Meitian, Cheng Genhong, Wang Hong-Wei, Liu Yingfang
Abstract excerpt
Replication and transcription of influenza virus genome mainly depend on its RNA-dependent RNA polymerase (RdRP), composed of the PA, PB1, and PB2 subunits. Although extensively studied, the underlying mechanism of the RdRP complex is still unclear. Here we report the biochemical characterization of influenza RdRP subcomplex comprising PA, PB1, and N terminus of PB2, which exist as dimer in solution and can...
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