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Article

Mutations in SARS-CoV-2 nsp7 and nsp8 proteins and their predicted impact on replication/transcription complex structure.

Journal of medical virology - 1 Jul 2021

Reshamwala Shamlan M S, Likhite Vishakha, Degani Mariam S, Deb Shalini S, Noronha Santosh B

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has been identified to be a mutation hot spot, with the P323L mutation being commonly observed in viral genomes isolated from North America. RdRp forms a complex with nonstructural proteins nsp7 and nsp8 to form the minimal replication/transcription machinery required for genome replication. As mutations in RdRp may...

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Identifiers

PMID: 33433004
DOI: 10.1002/jmv.26791
PMCID: PMC8012999

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