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Article

H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation.

Cell reports - 17 Nov 2020

Harutyunyan Ashot S, Chen Haifen, Lu Tianyuan, Horth Cynthia, Nikbakht Hamid, Krug Brian, Russo Caterina, Bareke Eric, Marchione Dylan M, Coradin Mariel, Garcia Benjamin A, Jabado Nada, Majewski Jacek

Abstract excerpt

The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenomics. Numerous studies have investigated the effect of this mutation on H3K27 trimethylation, but only recently have we started to realize its additional effects on the epigenome. Here, we use isogenic glioma H3K27M+/- cell lines to investigate H3K27 methylation and its interaction with H3K36 and H3K9 modifications. We...

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Identifiers

PMID: 33207202
DOI: 10.1016/j.celrep.2020.108390
PMCID: PMC7703850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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