Article
LRRK2 and vesicle trafficking.
Biochemical Society transactions - 1 Oct 2012
Sanna Giovanna, Del Giudice Maria Grazia, Crosio Claudia, Iaccarino Ciro
Abstract excerpt
Mutations in LRRK2 (leucine-rich repeat kinase 2) (also known as PARK8 or dardarin) are responsible for the autosomal-dominant form of PD (Parkinson's disease). LRRK2 mutations were found in approximately 3-5% of familial and 1-3% of sporadic PD cases with the highest prevalence (up to 40%) in No...
Topics
- Animals
- Cell Membrane
- Cytoplasmic Vesicles
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Parkinson Disease
- Protein Serine-Threonine Kinases