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Article

Chronic MPTP in Mice Damage-specific Neuronal Phenotypes within Dorsal Laminae of the Spinal Cord.

Neurotoxicity research - 1 Apr 2021

Biagioni Francesca, Vivacqua Giorgio, Lazzeri Gloria, Ferese Rosangela, Iannacone Simone, Onori Paolo, Morini Sergio, D'Este Loredana, Fornai Francesco

Abstract excerpt

The neurotoxin 1-methyl, 4-phenyl, 1, 2, 3, 6-tetrahydropiridine (MPTP) is widely used to produce experimental parkinsonism. Such a disease is characterized by neuronal damage in multiple regions beyond the nigrostriatal pathway including the spinal cord. The neurotoxin MPTP damages spinal motor neurons. So far, in Parkinson's disease (PD) patients alpha-synuclein aggregates are described in the dorsal horn of...

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Identifiers

PMID: 33206341
DOI: 10.1007/s12640-020-00313-x
PMCID: PMC7936970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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