Back to search

Article

Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitis

2024-02-13

Abstract excerpt

Parkinson’s disease (PD) is characterized by a decades-long prodrome, consisting of a collection of non-motor symptoms that emerges prior to the motor manifestation of the disease. Of these non-motor symptoms, gastrointestinal dysfunction and deficits attributed to central norepinephrine (NE) loss, including mood changes and sleep disturbances, are frequent in the PD population and emerge early in the disease. Evi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bb144877-985f-5a75-91d4-1d16f3cfa62a
DOI
10.1101/2024.02.12.580010
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitisDOI 10.1101/2024.02.12.580010
Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitisSemantic proximity
Intragastric administration of low-dose rotenone post-colitis exacerbates damage to the nigrostriatal dopaminergic system in Parkinson’s disease: The pace accelerates even moreSemantic proximity
Loss of nucleobindin-2 causes nigrastriatal degeneration in mice by impacting circadian rhythm-related genes and gut microbiotaSemantic proximity
Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathologySemantic proximity
A molecular convergence in the triad of Parkinson's disease, depressive disorder and gut health is revealed by the inflammation-miRNA axisSemantic proximity
Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote symptoms of Parkinson’s diseaseSemantic proximity
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleusSemantic proximity
The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative DiseaseSemantic proximity
DSS-induced inflammation in the colon drives a pro-inflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimodSemantic proximity
A molecular convergence in the triad of Parkinson’s disease, depressive disorder and gut health is revealed by the inflammation-miRNA axisSemantic proximity
The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative DiseaseSemantic proximity
A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitisSemantic proximity
Select a neighboring publication to make it the new centre.