Article
The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease.
Scientific reports - 12 Apr 2021
McQuade Rachel M, Singleton Lewis M, Wu Hongyi, Lee Sophie, Constable Remy, Di Natale Madeleine, Ringuet Mitchell T, Berger Joel P, Kauhausen Jessica, Parish Clare L, Finkelstein David I, Furness John B, Diwakarla Shanti
Abstract excerpt
Parkinson's disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervous system (ENS) of commonly used mouse models of PD that exhibit central neuropathy and a gut phenotype. Enteric neuropathy was assessed in five mouse models: peripheral injection of MPTP; intracerebral injection of 6-OHDA; oral rotenone; and mice transgenic for A53T variant human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.