Article
Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice.
Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2007
Rommelfanger K S, Edwards G L, Freeman K G, Liles L C, Miller G W, Weinshenker D
Abstract excerpt
Although Parkinson's disease (PD) is characterized primarily by loss of nigrostriatal dopaminergic neurons, there is a concomitant loss of norepinephrine (NE) neurons in the locus coeruleus. Dopaminergic lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are commonly used to model PD, and although MPTP effectively mimics the dopaminergic neuropathology of PD in mice, it fails to produce...
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