Article
Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum.
Epidemiology and psychiatric sciences - 17 Nov 2020
Pries L-K, Dal Ferro G A, van Os J, Delespaul P, Kenis G, Lin B D, Luykx J J, Richards A L, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Şahin Cankurtaran E, Ulusoy Kaymak S, Mihaljevic M M, Andric Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P A, García-Portilla M Paz, Sanjuan J, Aguilar E J, Santos J L, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N P, Atbaşoğlu C, Ucok A, Alptekin K, Can Saka M, Arango C, O'Donovan M, Tosato S, Rutten B P F, Guloksuz S
Abstract excerpt
AIMS: Psychosis spectrum disorder has a complex pathoetiology characterised by interacting environmental and genetic vulnerabilities. The present study aims to investigate the role of gene-environment interaction using aggregate scores of genetic (polygenic risk score for schizophrenia (PRS-SCZ)) and environment liability for schizophrenia (exposome score for schizophrenia (ES-SCZ)) across the psychosis...
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