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Examining Gene-Environment Interactions Using Aggregate Scores in a First-Episode Psychosis Cohort.

Schizophrenia bulletin - 8 Jul 2020

Mas Sergi, Boloc Daniel, Rodríguez Natalia, Mezquida Gisela, Amoretti Silvia, Cuesta Manuel J, González-Peñas Javier, García-Alcón Alicia, Lobo Antonio, González-Pinto Ana, Corripio Iluminada, Vieta Eduard, Castro-Fornieles Josefina, Mané Anna, Saiz-Ruiz Jeronimo, Gassó Patricia, Bioque Miquel, Bernardo Miquel

Abstract excerpt

Gene-environment (GxE) interactions have been related to psychosis spectrum disorders, involving multiple common genetic variants in multiple genes with very small effect sizes, and several environmental factors that constitute a dense network of exposures named the exposome. Here, we aimed to analyze GxE in a cohort of 310 first-episode psychotic (FEP) and 236 healthy controls, by using aggregate scores...

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Identifiers

PMID: 32083289
DOI: 10.1093/schbul/sbaa012
PMCID: PMC7342095

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