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Article

Evaluating the Exposome Score for Schizophrenia in a Transdiagnostic Psychosis Cohort: Associations With Psychosis Risk, Symptom Severity, and Personality Traits.

Schizophrenia bulletin - 8 Sept 2025

Kromenacker Bryan, Yassin Walid, Keshavan Matcheri, Parker David, Thakkar Vishal J, Pearlson Godfrey, Keedy Sarah, McDowell Jennifer, Gershon Elliot, Ivleva Elena, Hill S Kristian, Clementz Brett A, Tamminga Carol A

Abstract excerpt

BACKGROUND: Investigations of causal pathways for psychosis can be guided by the identification of environmental risk factors. A recently developed composite risk tool, the exposome score for schizophrenia (ES-SCZ), which controls for intercorrelations between risk factors, has shown fair to good performance. We tested the transdiagnostic psychosis classifier performance of the ES-SCZ with the...

Read the complete abstract on PubMed

Topics

Case-Control Studies
Cross-Sectional Studies
Phenotype
Psychotic Disorders
Schizophrenia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Exposome

Regression Analysis

Models, Psychological

Reproducibility of Results

Odds Ratio

Risk Factors

Severity of Illness Index

Symptom Burden

Risk Assessment

Clinical Relevance

Humans

Male

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 39777534
DOI: 10.1093/schbul/sbae219
PMCID: PMC12414550

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