Article
Balancing selection and high genetic diversity of Plasmodium vivax circumsporozoite central region in parasites from Brazilian Amazon and Rio de Janeiro Atlantic Forest.
PloS one - 1 Jan 2020
Almeida-de-Oliveira Natália Ketrin, Abreu-Fernandes Rebecca de, Lima-Cury Lidiane, Lavigne Aline Rosa de, Pina-Costa Anielle de, Perce-da-Silva Daiana de Souza, Catanho Marcos, Rossi Atila Duque, Brasil Patrícia, Daniel-Ribeiro Cláudio Tadeu, Ferreira-da-Cruz Maria de Fátima
Abstract excerpt
Circumsporozoite protein (CSP) is the primary pre-erythrocytic vaccine target in Plasmodium species. Knowledge about their genetic diversity can help predict vaccine efficacy and the spread of novel parasite variants. Thus, we investigated pvcsp gene polymorphisms in 219 isolates (136 from Brazilian Amazon [BA], 71 from Rio de Janeiro Atlantic Forest [AF], and 12 from non-Brazilian countries [NB]). Forty-eight...
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