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Article

Extensive genetic diversity of Plasmodium vivax dbp-II in Rio de Janeiro Atlantic Forest and Brazilian Amazon Basin: evidence of positive selection.

Malaria journal - 19 Feb 2020

Almeida-de-Oliveira Natália Ketrin, Lima-Cury Lidiane, de Abreu-Fernandes Rebecca, de Rosa Lavigne Aline, de Pina-Costa Anielle, de Souza Perce-da-Silva Daiana, Catanho Marcos, Brasil Patrícia, Daniel-Ribeiro Cláudio Tadeu, Ferreira-da-Cruz Maria de Fátima

Abstract excerpt

BACKGROUND: Plasmodium vivax is the most widespread human malaria parasite outside Africa and is the predominant parasite in the Americas. Increasing reports of P. vivax disease severity, together with the emergence of drug-resistant strains, underscore the urgency of the development of vaccines against P. vivax. Polymorphisms on DBP-II-gene could act as an immune evasion mechanism and, consequently, limited the...

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Identifiers

PMID: 32075659
DOI: 10.1186/s12936-020-03159-y
PMCID: PMC7031913

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