Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon.

doi:10.1038/s41598-020-70893-3

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Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon.

Scientific reports - 20 Aug 2020

Soares Isabela Ferreira, López-Camacho César, Rodrigues-da-Silva Rodrigo Nunes, da Silva Matos Ada, de Oliveira Baptista Barbara, Totino Paulo Renato Rivas, de Souza Rodrigo Medeiros, Harrison Kate, Gimenez Alba Marina, de Freitas Elisângela Oliveira, Kim Young Chan, Oliveira-Ferreira Joseli, Daniel-Ribeiro Cláudio Tadeu, Reyes-Sandoval Arturo, Pratt-Riccio Lilian Rose, Lima-Junior Josué da Costa

Abstract excerpt

Circumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein repetitive portion, can differ from each other in aspects such as geographical distribution, intensity of transmission, vectorial competence and immune response. Such aspects must be considered to P. vivax vaccine development. Therefore, we evaluated the immunogenicity of novel recombinant proteins corresponding to each...

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PMID: 32820195
DOI: 10.1038/s41598-020-70893-3
PMCID: PMC7441389

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