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Article

Antigenic diversity of the Plasmodium vivax circumsporozoite protein in parasite isolates of Western Colombia.

The American journal of tropical medicine and hygiene - 1 Feb 2011

Hernández-Martínez Miguel Ángel, Escalante Ananías A, Arévalo-Herrera Myriam, Herrera Sócrates

Abstract excerpt

Circumsporozoite (CS) protein is a malaria antigen involved in sporozoite invasion of hepatocytes, and thus considered to have good vaccine potential. We evaluated the polymorphism of the Plasmodium vivax CS gene in 24 parasite isolates collected from malaria-endemic areas of Colombia. We sequenced 27 alleles, most of which (25/27) corresponded to the VK247 genotype and the remainder to the VK210 type. All VK247...

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Identifiers

PMID: 21292878
DOI: 10.4269/ajtmh.2011.09-0785
PMCID: PMC3032490

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