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Article

Evolutionary dynamics of the immunodominant repeats of the Plasmodium vivax malaria-vaccine candidate circumsporozoite protein (CSP).

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2010

Patil Aarti, Orjuela-Sánchez Pamela, da Silva-Nunes Mônica, Ferreira Marcelo U

Abstract excerpt

The circumsporozoite protein (CSP) of Plasmodium vivax, a major target for malaria vaccine development, has immunodominant B-cell epitopes mapped to central nonapeptide repeat arrays. To determine whether rearrangements of repeat motifs during mitotic DNA replication of parasites create significant CSP diversity under conditions of low effective meiotic recombination rates, we examined csp alleles from sympatric...

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Identifiers

PMID: 20097310
DOI: 10.1016/j.meegid.2010.01.006
PMCID: PMC2849667

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