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Article

Loss of Ceacam1 promotes prostate cancer progression in Pten haploinsufficient male mice.

Metabolism: clinical and experimental - 1 Jun 2020

Liu Jehnan, Muturi Harrison T, Khuder Saja S, Helal Raghd Abu, Ghadieh Hilda E, Ramakrishnan Sadeesh K, Kaw Meenakshi K, Lester Sumona Ghosh, Al-Khudhair Ahmed, Conran Philip B, Chin Khew-Voon, Gatto-Weis Cara, Najjar Sonia M

Abstract excerpt

OBJECTIVE: PTEN haploinsufficiency plays an important role in prostate cancer development in men. However, monoallelic deletion of Pten gene failed to induce high prostate intraepithelial neoplasia (PIN) until Pten+/- mice aged or fed a high-calorie diet. Because CEACAM1, a cell adhesion molecule with a potential tumor suppression activity, is induced in Pten+/- prostates, the study aimed at examining whether the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32209360
DOI: 10.1016/j.metabol.2020.154215
PMCID: PMC7283002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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