Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

27 Mar 2020

Abstract excerpt

Gene dosage is a key defining factor to understand cancer pathogenesis and progression, which requires the development of experimental models that aid better deconstruction of the disease. Here, we model an aggressive form of prostate cancer and show the unconventional association of LKB1 dosage to prostate tumorigenesis. Whereas loss of Lkb1 alone in the murine prostate epithelium was inconsequential for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Genetic factors in colorectal cancer
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32219437
DOI: 10.1084/jem.20191787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancerPMID 32219437Read ↗

<i>Lkb1</i> Deficiency Causes Prostate Neoplasia in the MouseSemantic proximity Read ↗

LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancerSemantic proximity Read ↗

Heterogeneous Tumor Evolution Initiated by Loss of pRb Function in a Preclinical Prostate Cancer ModelSemantic proximity Read ↗

Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer FormationSemantic proximity Read ↗

Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis.Semantic proximity Read ↗

Genetic ablation of FASN attenuates the invasive potential of prostate cancer driven by Pten lossSemantic proximity Read ↗

PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis.Semantic proximity Read ↗

The tumor suppressor kinase LKB1: lessons from mouse modelsSemantic proximity Read ↗

Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancerSemantic proximity Read ↗

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.Semantic proximity Read ↗

No Tumor Suppressor Role for LKB1 in Prostate Cancer.Semantic proximity Read ↗

TLK1-MK5 axis drives prostate cancer cell motility and pathologic features of aggressivenessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.