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Article

Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2010

Nguyen Paul L, Ma Jing, Chavarro Jorge E, Freedman Matthew L, Lis Rosina, Fedele Giuseppe, Fiore Christopher, Qiu Weiliang, Fiorentino Michelangelo, Finn Stephen, Penney Kathryn L, Eisenstein Anna, Schumacher Fredrick R, Mucci Lorelei A, Stampfer Meir J, Giovannucci Edward, Loda Massimo

Abstract excerpt

PURPOSE: Fatty acid synthase (FASN) regulates de novo lipogenesis, body weight, and tumor growth. We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality and whether these effects vary by body mass index (BMI). METHODS: In a prospective nested case-control study of 1,331 white patients with PCa and 1,267 age-matched...

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Identifiers

PMID: 20679621
DOI: 10.1200/JCO.2009.27.0793
PMCID: PMC2940394

Genes

FASN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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