Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes.

doi:10.7554/eLife.62522

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Article

Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes.

eLife - 9 Nov 2020

Wang Allen, Chiou Joshua, Poirion Olivier B, Buchanan Justin, Valdez Michael J, Verheyden Jamie M, Hou Xiaomeng, Kudtarkar Parul, Narendra Sharvari, Newsome Jacklyn M, Guo Minzhe, Faddah Dina A, Zhang Kai, Young Randee E, Barr Justinn, Sajti Eniko, Misra Ravi, Huyck Heidie, Rogers Lisa, Poole Cory, Whitsett Jeffery A, Pryhuber Gloria, Xu Yan, Gaulton Kyle J, Preissl Sebastian, Sun Xin

Abstract excerpt

Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased lungs from donors of ~30 weeks gestation,~3 years and ~30 years. We mapped candidate cis-regulatory elements (cCREs) and linked them to putative target genes. We identified distal cCREs...

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PMID: 33164753
DOI: 10.7554/eLife.62522
PMCID: PMC7688309

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