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A Multimodal Spatial and Epigenomic Atlas of Human Adult Lung Topography

2025-05-24

Abstract excerpt

Developing high-resolution reference maps of disease-susceptible spatial niches is a critical step to mitigating the profound effects of lung disease. Here, we present an integrated multimodal single-nucleus human lung atlas (snHLA) profiling 746,047 nuclei from 49 mapped lung blocks spanning clinically relevant distal airways, alveoli, and interstitium across 11 healthy adults. Integrating snRNA-seq and SNARE-seq...

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Literature Corpus work
c0dff175-b239-5be6-9a6e-88965bbea973
DOI
10.1101/2025.05.23.655666
Open publication

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A Multimodal Spatial and Epigenomic Atlas of Human Adult Lung TopographyDOI 10.1101/2025.05.23.655666
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