Article

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

2020-04-20

Abstract excerpt

<h4>ABSTRACT</h4> The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Cell membrane bound angiotensin-converting enzyme 2 (ACE2) and associated proteases, transmembrane protease serine 2 (TMPRSS2) and Cathepsin L (CTSL), were previously identified as mediators of SARS-CoV2 cellul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23f1001f-604e-5528-9d59-a422f9823c61
DOI: 10.1101/2020.04.19.049254

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cellsDOI 10.1101/2020.04.19.049254Read

Single-cell analysis of human lung epithelia reveals concomitant expression of the SARS-CoV-2 receptor ACE2 with multiple virus receptors and scavengers in alveolar type II cellsSemantic proximity Read

The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infectionSemantic proximity Read

Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal CellsSemantic proximity Read

The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection.Semantic proximity Read

SARS-CoV-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients by single-cell sequencingSemantic proximity Read

Expression of ACE2, TMPRSS2 and CTSL in human airway epithelial cells under physiological and pathological conditions: Implications for SARS-CoV-2 infectionSemantic proximity Read

SARS-CoV-2 Targets by the pscRNA Profiling of ACE2, TMPRSS2 and Furin ProteasesSemantic proximity Read

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronavirusesSemantic proximity Read

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2Semantic proximity Read

Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19Semantic proximity Read

SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cellsSemantic proximity Read