Article

Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection

2020-04-14

Abstract excerpt

<h4>SUMMARY</h4> Respiratory failure is the leading cause of COVID-19 death and disproportionately impacts adults more than children. Here, we present a large-scale snATAC-seq dataset (90,980 nuclei) of the human lung, generated in parallel with snRNA-seq (46,500 nuclei), from healthy donors of ~30 weeks, ~3 years and ~30 years of age. Focusing on genes implicated in SARS-CoV-2 cell entry, we observed an increase...

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Literature Corpus work: 43f9dceb-ca5c-5d5d-b382-bce4a7f6d305
DOI: 10.1101/2020.04.12.037580

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