Article
Species-specific codon context rules unveil non-neutrality effects of synonymous mutations.
PloS one - 1 Jan 2011
Moura Gabriela R, Pinheiro Miguel, Freitas Adelaide, Oliveira José L, Frommlet Jörg C, Carreto Laura, Soares Ana R, Bezerra Ana R, Santos Manuel A S
Abstract excerpt
BACKGROUND: Codon pair usage (codon context) is a species specific gene primary structure feature whose evolutionary and functional roles are poorly understood. The data available show that codon-context has direct impact on both translation accuracy and efficiency, but one does not yet understand how it affects these two translation variables or whether context biases shape gene evolution....
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