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Article

The Roots of Genetic Coding in Aminoacyl-tRNA Synthetase Duality.

Annual review of biochemistry - 20 Jun 2021

Carter Charles W, Wills Peter R

Abstract excerpt

Codon-dependent translation underlies genetics and phylogenetic inferences, but its origins pose two challenges. Prevailing narratives cannot account for the fact that aminoacyl-tRNA synthetases (aaRSs), which translate the genetic code, must collectively enforce the rules used to assemble themselves. Nor can they explain how specific assignments arose from rudimentary differentiation between ancestral aaRSs and...

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PMID: 33781075
DOI: 10.1146/annurev-biochem-071620-021218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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