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Article

Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations.

Mediators of inflammation - 1 Jan 2020

Santiago Rayra P, Figueiredo Camylla V B, Fiuza Luciana M, Yahouédéhou Sètondji C M A, Oliveira Rodrigo M, Aleluia Milena M, Carvalho Suellen P, Fonseca Cleverson A, Nascimento Valma M L, Rocha Larissa C, Guarda Caroline C, Gonçalves Marilda S

Abstract excerpt

Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation. Polymorphisms in the transforming growth factor-beta receptor 3 (TGFBR3) gene have been linked to several inflammatory diseases. This study investigated associations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33149723
DOI: 10.1155/2020/3185015
PMCID: PMC7603616

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