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Article

Frequencies of -308G/A (TNFA) and -509C/T (TGFB1) polymorphisms in sickle cell anemia patients from Brazil.

Genetics and molecular research : GMR - 16 Dec 2013

Torres L S, Belini Júnior E, Silva D G, Lobo C L, Ruiz M A, Bonini-Domingos C R

Abstract excerpt

Sickle cell anemia is an affection that causes chronic inflammation, with consequences for vaso-occlusion, oxidative stress and cytokine production. Genetic polymorphisms in markers involved in this process can modulate the inflammatory response, including polymorphisms -308G/A of TNFA (tumor necrosis factor alpha) and -509C/T of TGFB1 (transforming growth factor beta 1), reported to increase TNF-α and TGF-β1...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemoglobin, Sickle

Share to Polymorphism, Restriction Fragment Length

Share to Polymorphism, Single Nucleotide

Share to Transforming Growth Factor beta1

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Source

Identifiers

PMID: 24391023
DOI: 10.4238/2013.December.16.1

Genes

TGFB1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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