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Article

TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia.

Disease markers - 1 Jan 2020

Santiago Rayra Pereira, Figueiredo Camylla Vilas Boas, Fiuza Luciana Magalhães, Yahouédéhou Sétondji Cocou Modeste Alexandre, Oliveira Rodrigo Mota, Aleluia Milena Magalhães, Carvalho Suellen Pinheiro, Fonseca Cleverson Alves, Nascimento Valma Maria Lopes, Rocha Larissa Carneiro, Guarda Caroline Conceição, Gonçalves Marilda Souza

Abstract excerpt

Individuals with sickle cell anemia (SCA) present chronic anemia, hemolysis, an exacerbated inflammatory response, and heterogeneous clinical complications, which may be modulated by the transforming growth factor beta (TGF-β) pathway. Thus, we aimed to investigate polymorphisms (rs1805110 and rs7526590) of the transforming growth factor beta receptor III gene (TGFBR3) with regard to laboratory biomarkers and...

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Identifiers

PMID: 33062074
DOI: 10.1155/2020/8867986
PMCID: PMC7547350

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