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Evolution from adherent to suspension: systems biology of HEK293 cell line development

4 Nov 2020

Abstract excerpt

The need for new safe and efficacious therapies has led to an increased focus on biologics produced in mammalian cells. The human cell line HEK293 has bio-synthetic potential for human-like production attributes and is currently used for manufacturing of several therapeutic proteins and viral vectors. Despite the increased popularity of this strain we still have limited knowledge on the genetic composition of its...

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PMID: 33149219
DOI: 10.1038/s41598-020-76137-8

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