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Article

Comparative Analysis of HEK293 Genomic Variability.

Biotechnology and bioengineering - 1 Feb 2026

Smesnik Georg, Virgolini Nikolaus, Toth Maria, Dürauer Astrid, Borth Nicole

Abstract excerpt

Human embryonic kidney cells HEK293 are widely used in biopharmaceutical manufacturing, with a recent surge particularly in recombinant adeno-associated virus production. Despite their industrial relevance, comprehensive data on their genomic background and stability remains limited. Here, we systematically analyze the genetic landscape of various HEK293 cell lines in response to cultivation conditions, clonal...

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Identifiers

PMID: 41211952
DOI: 10.1002/bit.70105
PMCID: PMC12779178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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