Phenotypes and Multi-omics Reveal Changes and Molecular Mechanism of Suspension Adaptation of HEK293 Cells: Structural Remodelling, Metabolic Reconstruction and Stress Resistance

Abstract excerpt

<title>Abstract</title> <p>Human embryonic kidney 293 (HEK293) cells have been successfully adapted from adherent to suspension culture and have been widely applied in both scientific research and the pharmaceutical industry. However, the alterations in cells during the adaptation have not been well described, which raise some uncertainties and concerns regarding the underlying changes and cell behavior. In this...

Topics

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• 3D Printing in Biomedical Research
• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Monoclonal and Polyclonal Antibodies Research
• Pancreatic function and diabetes
• RNA and protein synthesis mechanisms
• Viral Infectious Diseases and Gene Expression in Insects
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

7a737513-af88-5775-9186-9ce3167c20b1

DOI

10.21203/rs.3.rs-8498955/v1