Article

Adeno-associated and lentiviral vector production in 2D and 3D formats with adherent cells in chemically defined, blood-free media

2021-09-27

Abstract excerpt

Large scale manufacturing of viral vectors or vaccines with adherent cells still relies heavily on the inclusion of fetal bovine serum for the growth and production phases. The inclusion of serum presents numerous problems with the undefined chemical makeup, the undesirable safety profile, and the constraints and limitations on the global supply. Despite these challenges, alternatives to serum for adherent cells h...

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Literature Corpus work: 9e994506-a5f7-5b0d-a89b-ac425479c2f6
DOI: 10.22541/au.163272364.46529262/v1

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