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Transcriptomic functional characterization of recombinant adeno‐associated virus producing cell line adapted to suspension‐growth

21 May 2025

Abstract excerpt

Recombinant adeno-associated virus (rAAV) is a widely used delivery vehicle in gene therapy. A scalable production technology is essential for its wide clinical applications. We have taken a synthetic biology approach to generate HEK293-based cell lines which harbor integrated genetic elements encoding essential AAV and adenoviral helper components and can be induced to produce rAAV. Through cycles of cell line...

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PMID: 40396307
DOI: 10.1002/btpr.70042

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