Article
Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice.
Genes, brain, and behavior - 1 Mar 2021
Bryant Camron D, Healy Aidan F, Ruan Qiu T, Coehlo Michal A, Lustig Elijah, Yazdani Neema, Luttik Kimberly P, Tran Tori, Swancy Isaiah, Brewin Lindsey W, Chen Melanie M, Szumlinski Karen K
Abstract excerpt
Opioid Use Disorder (OUD) and opioid-related deaths remain a major public health concern in the United States. Both environmental and genetic factors influence risk for OUD. We previously identified Hnrnph1 as a quantitative trait gene underlying the stimulant, rewarding, and reinforcing properties of methamphetamine. Prior work shows that hnRNP H1, the RNA-binding protein encoded by Hnrnph1,...
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