Article
A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Aug 2014
Xu Jin, Lu Zhigang, Xu Mingming, Pan Ling, Deng Yi, Xie Xiaohu, Liu Huifen, Ding Shixiong, Hurd Yasmin L, Pasternak Gavril W, Klein Robert J, Cartegni Luca, Zhou Wenhua, Pan Ying-Xian
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in the OPRM1 gene have been associated with vulnerability to opioid dependence. The current study identifies an association of an intronic SNP (rs9479757) with the severity of heroin addiction among Han-Chinese male heroin addicts. Individual SNP analysis and haplotype-based analysis with additional SNPs in the OPRM1 locus showed that mild heroin addiction was associated...
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