Article
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.
Molecular psychiatry - 1 Mar 2017
Smith A H, Jensen K P, Li J, Nunez Y, Farrer L A, Hakonarson H, Cook-Sather S D, Kranzler H R, Gelernter J
Abstract excerpt
Opioids are very effective analgesics, but they are also highly addictive. Methadone is used to treat opioid dependence (OD), acting as a selective agonist at the μ-opioid receptor encoded by the gene OPRM1. Determining the optimal methadone maintenance dose is time consuming; currently, no biomarkers are available to guide treatment. In methadone-treated OD subjects drawn from a case and control sample, we...
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