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Article

Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2012

Litteri Gaia, Carnevale Daniela, D'Urso Alessandra, Cifelli Giuseppe, Braghetta Paola, Damato Antonio, Bizzotto Dario, Landolfi Alessandro, Ros Francesco Da, Sabatelli Patrizia, Facchinello Nicola, Maffei Angelo, Volpin Dino, Colombatti Alfonso, Bressan Giorgio M, Lembo Giuseppe

Abstract excerpt

OBJECTIVE: Emilin-1 is a protein of elastic extracellular matrix involved in blood pressure (BP) control by negatively affecting transforming growth factor (TGF)-β processing. Emilin1 null mice are hypertensive. This study investigates how Emilin-1 deals with vascular mechanisms regulating BP. METHODS AND RESULTS: This study uses a phenotype rescue approach in which Emilin-1 is expressed in either endothelial...

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Identifiers

PMID: 22814752
DOI: 10.1161/ATVBAHA.112.254664

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