Article
Alanine mutation of the targeting subunit of the myosin phosphatase, MYPT1 at threonine 696 reduces cGMP responsiveness of mouse femoral arteries.
European journal of pharmacology - 5 Jan 2025
Lubomirov Lubomir T, Weber Greta, Schroeter Mechthild, Metzler Doris, Bust Maria, Korotkova Tatiana, Hescheler Jürgen, Todorov Vladimir T, Pfitzer Gabriele, Grisk Olaf
Abstract excerpt
The femoral artery (FA) is the largest vessel in the hindlimb circulation and its proper tone regulation ensures adequate blood supply to muscle tissue. We investigated whether an alanine mutation of the targeting subunit of myosin-light-chain-phosphatase (MLCP), MYPT1, at threonine 696 (MYPT1-T696A/+), decisive for enzyme acivity, affects the responsiveness of young and old FAs (y-FAs and o-FAs) to activation of...
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