The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

Abstract excerpt

Human cells lacking RIF1 are highly sensitive to replication inhibitors, but the reasons for this sensitivity have been enigmatic. Here, we show that RIF1 must be present both during replication stress and in the ensuing recovery period to promote cell survival. Of two isoforms produced by alternative splicing, we find that RIF1-Long alone can protect cells against replication inhibition, but RIF1-Short is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to CRISPR and Genetic Engineering
• Share to DNA Repair Mechanisms