Article

53BP1 nuclear body-marked replication stress in a human mammary cell model of BRCA2 deficiency

2018-11-05

Abstract excerpt

BRCA2 deficiency causes genome instability and breast and ovarian cancer predisposition, but also paradoxically promotes cell lethality. The nature of the acute, detrimental consequences of BRCA2 loss is not fully understood. We recently generated BRCA2 conditional models from a non-transformed human mammary cell line, through allele-specific gene targeting using CRISPR-Cas9, which we now describe. With these mod...

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Literature Corpus work: cf2a08ef-b94c-54d5-8fbe-20ece4e7f0b1
DOI: 10.1101/462119

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