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Article

Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition.

Scientific reports - 31 Oct 2023

Cardoso Dos Santos Luís Miguel, Azar Pascal, Brun Cécile, König Stéphane, Roatti Angela, Baertschi Alex J, Chaabane Chiraz, Bochaton-Piallat Marie-Luce

Abstract excerpt

During atherosclerotic plaque formation, smooth muscle cells (SMCs) switch from a contractile/differentiated to a synthetic/dedifferentiated phenotype. We previously isolated differentiated spindle-shaped (S) and dedifferentiated rhomboid (R) SMCs from porcine coronary artery. R-SMCs express S100A4, a calcium-binding protein. We investigated the role of apelin in this phenotypic conversion, as well as its...

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Identifiers

PMID: 37907514
DOI: 10.1038/s41598-023-45470-z
PMCID: PMC10618247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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