Article
Gene mutations in myelodysplasia.
Leukemia research - 1 Jan 1992
Jacobs A
Abstract excerpt
The myelodysplastic syndrome is a paradigm of human preleukaemia. Normal haemopoiesis is progressively displaced by an abnormal clone derived from a mutated stem cell. The initial mutation is unknown but its occurrence may be related to the overall load of random mutations which are a consequence of both intrinsic DNA defects and external mutagens. Evolution of the pathological population is marked by an...
Topics
- Genes, fms
- Genes, ras
- Humans
- Mutation
- Myelodysplastic Syndromes